My personal choice
I have tried several small pocket pistols in the past, but none of them quite suited me. I bought a Taurus ultralite revolver a couple of years ago, bobbed the hammer and added lazer grips. It rides in my right front pocket in an Uncle Mikes size 36 nylon clip holster(to break up the outline and keep out some pocket lint), loaded with Speer +p hollow points. It is virtually undetectable in loose fitting khakis and is light enough to carry all the time. Yes, I would rather have my .45 if the situation calls for a handgun, but sometime it is not convenient to carry a full size pistol and a revolver is much less likely to malfunction from pocket lint and grit than a small auto loader. The bottom line is get something that you are comfortable with and carry it all the time. A .22 in your pocket is better than a .45 at home in the safe.