You might get by with the little bullets from 250-350 grs. but the 500 gr. ones won't be pleasant in that little light rifle. Can't speak for the .500 S&W but I loaded up some 45-70 cartridges for a buddy of mine that has the Handi-Rifle...he insisted on big ones and wanted to try my 535 gr. Postell bullets...so I fixed him up. First shot thumped him right between the horns...second shot knocked him off the bucket he was sitting on.