For hunting I’ve found that large slow moving rounds, .50 muzzleloader or .45-70 in particular, kill quickly with almost no damage to the meat. While a fast moving smaller caliber, .223, .243, .30-‘06, .300Win, etc., damage (bloodshot) far more meat than the large slow movers and don’t kill any quicker.Would you rather build a 450 Bushmaster AR? Or a 6.5 Grendel for up to 200 yards but mostly under 150 yards. I think they are both AR, not A10. I see a lot of 308 uppers now. The 450 goes back to the old argument big heavy bullet vs. small fast bullet. Although the 450 is going over 2.000 fps.
That being said I only hunt with 30-‘06 or .223 these days. Neck shots being my intention it doesn’t make much difference, IMO.